Drug rash due to levamisole.

Levamisole, a commonly used anti-helminthic, has been found to have microfilaricidal, immunostimulant and immunomodulator activities. Its side effects include nausea and vomiting, metallic taste, diarrhea, malaise, insomnia, sensory stimulation, hyperallergic state, dizziness, headache, blurred vision, fatigue and fever. Prolonged use of this drug may cause agranulocytosis, cutaneous necrosis, vasculitis, ataxia, purpura involving the ear, thrombocytopenia and psychosis. Hypersensitivity due to levamisole is rare. Recently, we reported a case of fever due to levamisole. Here we report a patient of vitiligo who developed repeated episodes of fever along with itching and redness of the palms, soles and legs on intake of levamisole. On rechallenge with levamisole he developed the same symptoms within 5 hours.